Marada A, Walter C, Suhm T, Shankar S, Nandy A, Brummer T, Dhaouadi I, Vögtle FN, Meisinger C

DYRK1A signalling synchronizes the mitochondrial import pathways for metabolic rewiring.

Moretti-Horten DN, Peselj C, Taskin AA, Myketin L, Schulte U, Einsle O, Drepper F, Luzarowski M, Vögtle FN

Synchronized assembly of the oxidative phosphorylation system controls mitochondrial respiration in yeast.

Taskin AA, Moretti DN, Vögtle FN, Meisinger C

Isolation and Quality Control of Yeast Mitochondria.

Diessl J, Berndtsson J, Broeskamp F, Habernig L, Kohler V, Vazquez-Calvo C, Nandy A, Peselj C, Drobysheva S, Pelosi L, Vögtle FN, Pierrel F, Ott M, Büttner S

Manganese-driven CoQ deficiency.

Schimanski B, Aeschlimann S, Stettler P, Käser S, Gomez-Fabra Gala M, Bender J, Warscheid B, Vögtle FN, Schneider A

p166 links membrane and intramitochondrial modules of the trypanosomal tripartite attachment complex.

Ring J, Tadic J, Ristic S, Poglitsch M, Bergmann M, Radic N, ..., Dammbrueck C, Hofer SJ, Abdellatif M, Grundmeier G, Kroemer G, Braun RJ, Hansen N, Sommer C, Ninkovic M, Seba S, Rockenfeller P, Vögtle FN, Dengjel J, Meisinger C, Keller A, Sigrist SJ, Eisenberg T, Madeo F

The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity.

Peselj C, Ebrahimi M, Broeskamp F, Prokisch S, Habernig L, Alvarez-Guerra I, Kohler V, Vögtle FN, Büttner S

Sterol Metabolism Differentially Contributes to Maintenance and Exit of Quiescence.

Vögtle FN, Koch HG, Meisinger C

A common evolutionary origin reveals fundamental principles of protein insertases.

Vögtle FN, Meisinger C

Mitochondria as emergency landing for abandoned peroxins.

Walter C, Marada A, Suhm T, Ernsberger R, Muders V, Kücükköse C, Sánchez-Martín P, Hu Z, Aich A, Loroch S, Solari FA, Poveda-Huertes D, Schwierzok A, Pommerening H, Matic S, Brix J, Sickmann A, Kraft C, Dengjel J, Dennerlein S, Brummer T, Vögtle FN, Meisinger C

Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery.

Poveda-Huertes D, Taskin AA, Dhaouadi I, Myketin L, Marada A, Habernig L, Büttner S, Vögtle FN

Increased mitochondrial protein import and cardiolipin remodelling upon early mtUPR.

Tosal-Castano S, Peselj C, Kohler V, Habernig L, Berglund LL, Ebrahimi M, Vögtle FN, Höög J, Andréasson C, Büttner S

Snd3 controls nucleus-vacuole junctions in response to glucose signaling.

Gomez-Fabra Gala M, Vögtle FN

Mitochondrial proteases in human diseases.

Vögtle FN

Open questions on the mitochondrial unfolded protein response.

Kücükköse C, Taskin AA, Marada A, Brummer T, Dennerlein S, Vögtle FN

Functional coupling of presequence processing and degradation in human mitochondria.

Makepeace KAT, Mohammed Y, Rudashevskaya EL, Petrotchenko EV, Vögtle FN, Meisinger C, Sickmann A, Borchers CH

Improving Identification of In-organello Protein-Protein Interactions Using an Affinity-enrichable, Isotopically Coded, and Mass Spectrometry-cleavable Chemical Crosslinker.

Taskin AA, Poveda-Huertes D, Vögtle FN

Author's View: a nuclear transcription factor relocalizing to mitochondria rescues cells from proteotoxic aggregates.

Poveda-Huertes D, Matic S, Marada A, Habernig L, Licheva M, Myketin L, Gilsbach R, Tosal-Castano S, Papinski D, Mulica P, Kretz O, Kücükköse C, Taskin AA, Hein L, Kraft C, Büttner S, Meisinger C, Vögtle FN

An Early mtUPR: Redistribution of the Nuclear Transcription Factor Rox1 to Mitochondria Protects against Intramitochondrial Proteotoxic Aggregates.

Niemi NM, Wilson GM, Overmyer KA, Vögtle FN, Myketin L, Lohman DC, Schueler KL, Attie AD, Meisinger C, Coon JJ, Pagliarini DJ

Pptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis.

Heublein M, Ndi M, Vazquez-Calvo C, Vögtle FN, Ott M

Alternative Translation Initiation at a UUG Codon Gives Rise to Two Functional Variants of the Mitochondrial Protein Kgd4.

Aufschnaiter A, Kohler V, Walter C, Tosal-Castano S, Habernig L, Wolinski H, Keller W, Vögtle FN, Büttner S

The Enzymatic Core of the Parkinson's Disease-Associated Protein LRRK2 Impairs Mitochondrial Biogenesis in Aging Yeast.

Vögtle FN, Brändl B, Larson A, Pendziwiat M, Friederich MW, White SM, ..., Walsh M, Yu HC, Shinde DN, Stephani U, Van Hove JLK, Müller FJ, Helbig I

Mutations in PMPCB Encoding the Catalytic Subunit of the Mitochondrial Presequence Protease Cause Neurodegeneration in Early Childhood.

Carmona-Gutierrez D, Bauer MA, Zimmermann A, ..., Vögtle FN, Westermann B, Winderickx J, Wissing S, Wölfl S, Zhang ZJ, Zhao RY, Zhou B, Galluzzi L, Kroemer G, Madeo F

Guidelines and recommendations on yeast cell death nomenclature.

Kravic B, Harbauer AB, Romanello V, Simeone L, Vögtle FN, Kaiser T, Straubinger M, Huraskin D, Böttcher M, ..., Marber M, Salviati L, Mougiakakos D, Neuhuber W, Sandri M, Meisinger C, Hashemolhosseini S

In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy.

Krüger V, Becker T, Becker L, Montilla-Martinez M, Ellenrieder L, Vögtle FN, Meyer HE, Ryan MT, Wiedemann N, Warscheid B, Pfanner N, Wagner R, Meisinger C

Identification of new channels by systematic analysis of the mitochondrial outer membrane.

Vögtle FN, Burkhart JM, Gonczarowska-Jorge H, Kücükköse C, Taskin AA, Kopczynski D, Ahrends R, Mossmann D, Sickmann A, Zahedi RP, Meisinger C

Landscape of submitochondrial protein distribution.

Taskin AA, Kücükköse C, Burger N, Mossmann D, Meisinger C, Vögtle FN

The novel mitochondrial matrix protease Ste23 is required for efficient presequence degradation and processing.

Poveda-Huertes D, Mulica P, Vögtle FN

The versatility of the mitochondrial presequence processing machinery: cleavage, quality control and turnover.

Eldomery MK, Akdemir ZC, Vögtle FN, Charng WL, Mulica P, Rosenfeld JA, Gambin T, Gu S, Burrage LC, Al Shamsi A, Penney S, ..., Abdul-Rahman OA, Yang Y, Xia F, Wang MC, Lupski JR, Meisinger C, Sutton VR

MIPEP recessive variants cause a syndrome of left ventricular non-compaction, hypotonia, and infantile death.

Burkhart JM, Taskin AA, Zahedi RP, Vögtle FN

Quantitative Profiling for Substrates of the Mitochondrial Presequence Processing Protease Reveals a Set of Nonsubstrate Proteins Increased upon Proteotoxic Stress.

Vögtle FN, Keller M, Taskin AA, Horvath SE, Guan XL, Prinz C, Opalińska M, Zorzin C, van der Laan M, Wenk MR, Schubert R, Wiedemann N, Holzer M, Meisinger C

The fusogenic lipid phosphatidic acid promotes the biogenesis of mitochondrial outer membrane protein Ugo1.

Stroud DA, Maher MJ, Lindau C, Vögtle FN, Frazier AE, Surgenor E, Mountford H, Singh AP, Bonas M, Oeljeklaus S, Warscheid B, Meisinger C, Thorburn DR, Ryan MT

COA6 is a mitochondrial complex IV assembly factor critical for biogenesis of mtDNA-encoded COX2.

Pacheu-Grau D, Bareth B, Dudek J, Juris L, Vögtle FN, Wissel M, Leary SC, Dennerlein S, Rehling P, Deckers M

Cooperation between COA6 and SCO2 in COX2 maturation during cytochrome c oxidase assembly links two mitochondrial cardiomyopathies.

Mossmann D, Vögtle FN, Taskin AA, Teixeira PF, Ring J, Burkhart JM, Burger N, Pinho CM, Tadic J, Loreth D, Graff C, Metzger F, Sickmann A, Kretz O, Wiedemann N, Zahedi RP, Madeo F, Glaser E, Meisinger C

Amyloid-β peptide induces mitochondrial dysfunction by inhibition of preprotein maturation.

Heublein M, Burguillos MA, Vögtle FN, Teixeira PF, Imhof A, Meisinger C, Ott M

The novel component Kgd4 recruits the E3 subunit to the mitochondrial α-ketoglutarate dehydrogenase.

Ieva R, Heißwolf AK, Gebert M, Vögtle FN, Wollweber F, Mehnert CS, Oeljeklaus S, Warscheid B, Meisinger C, van der Laan M, Pfanner N

Mitochondrial inner membrane protease promotes assembly of presequence translocase by removing a carboxy-terminal targeting sequence.

Büttner S, Habernig L, Broeskamp F, Ruli D, Vögtle FN, Vlachos M, Macchi F, Küttner V, Carmona-Gutierrez D, Eisenberg T, Ring J, Markaki M, Taskin AA, ..., Dengjel J, Meisinger C, Sigrist SJ, Madeo F

Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease.

Venne AS, Vögtle FN, Meisinger C, Sickmann A, Zahedi RP

Novel highly sensitive, specific, and straightforward strategy for comprehensive N-terminal proteomics reveals unknown substrates of the mitochondrial peptidase Icp55.

Huai J, Vögtle FN, Jöckel L, Li Y, Kiefer T, Ricci JE, Borner C

TNFα-induced lysosomal membrane permeability is downstream of MOMP and triggered by caspase-mediated NDUFS1 cleavage and ROS formation.

Vögtle FN, Burkhart JM, Rao S, Gerbeth C, Hinrichs J, Martinou JC, Chacinska A, Sickmann A, Zahedi RP, Meisinger C

Intermembrane space proteome of yeast mitochondria.

Horvath SE, Böttinger L, Vögtle FN, Wiedemann N, Meisinger C, Becker T, Daum G

Processing and topology of the yeast mitochondrial phosphatidylserine decarboxylase 1.

Vögtle FN, Meisinger C

Sensing mitochondrial homeostasis: the protein import machinery takes control.

Wilfling F, Weber A, Potthoff S, Vögtle FN, Meisinger C, Paschen SA, Häcker G

BH3-only proteins are tail-anchored in the outer mitochondrial membrane and can initiate the activation of Bax.

Vukotic M, Oeljeklaus S, Wiese S, Vögtle FN, Meisinger C, Meyer HE, Zieseniss A, Katschinski DM, Jans DC, Jakobs S, Warscheid B, Rehling P, Deckers M

Rcf1 mediates cytochrome oxidase assembly and respirasome formation, revealing heterogeneity of the enzyme complex.

Mossmann D, Meisinger C, Vögtle FN

Processing of mitochondrial presequences.

Büttner S, Ruli D, Vögtle FN, Galluzzi L, Moitzi B, Eisenberg T, Kepp O, Habernig L, Carmona-Gutierrez D, Rockenfeller P, Laun P, Breitenbach M, Khoury C, Fröhlich KU, Rechberger G, Meisinger C, Kroemer G, Madeo F

A yeast BH3-only protein mediates the mitochondrial pathway of apoptosis.

Alikhani N, Berglund AK, Engmann T, Spånning E, Vögtle FN, Pavlov P, Meisinger C, Langer T, Glaser E

Targeting capacity and conservation of PreP homologues localization in mitochondria of different species.

Vögtle FN, Prinz C, Kellermann J, Lottspeich F, Pfanner N, Meisinger C

Mitochondrial protein turnover: role of the precursor intermediate peptidase Oct1 in protein stabilization.

Vögtle FN, Schmidt O, Chacinska A, Pfanner N, Meisinger C

Native techniques for analysis of mitochondrial protein import.

Vögtle FN, Wortelkamp S, Zahedi RP, Becker D, Leidhold C, Gevaert K, Kellermann J, Voos W, Sickmann A, Pfanner N, Meisinger C

Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability.

Becker T, Vögtle FN, Stojanovski D, Meisinger C

Sorting and assembly of mitochondrial outer membrane proteins.

Binder M, Vögtle FN, Michelfelder S, Müller F, Illerhaus G, Sundararajan S, Mertelsmann R, Trepel M

Identification of their epitope reveals the structural basis for the mechanism of action of the immunosuppressive antibodies basiliximab and daclizumab.

Sanjuán Szklarz LK, Kozjak-Pavlovic V, Vögtle FN, Chacinska A, Milenkovic D, Vogel S, Dürr M, Westermann B, Guiard B, Martinou JC, Borner C, Pfanner N, Meisinger C

Preprotein transport machineries of yeast mitochondrial outer membrane are not required for Bax-induced release of intermembrane space proteins.

Jäger S, Jahnke A, Wilmes T, Adebahr S, Vögtle FN, Delima-Hahn E, Pfeifer D, Berg T, Lübbert M, Trepel M

Leukemia-targeting ligands isolated from phage-display peptide libraries.